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Article

Both integrated and differential regulation of components of the IL-2/IL-2 receptor system.

Cytokine & growth factor reviews - 1 Oct 2006

Kim Hyoung Pyo, Imbert Jean, Leonard Warren J

Abstract excerpt

Interleukin-2 was discovered in 1976 as a T-cell growth factor. It was the first type I cytokine cloned and the first for which a receptor component was cloned. Its importance includes its multiple actions, therapeutic potential, and lessons for receptor biology, with three components differentially combining to form high, intermediate, and low-affinity receptors. IL-2Ralpha and IL-2Rbeta, respectively, are...

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PMID: 16911870
DOI: 10.1016/j.cytogfr.2006.07.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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