Article
Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID.
Science (New York, N.Y.) - 11 Nov 1994
Russell S M, Johnston J A, Noguchi M, Kawamura M, Bacon C M, Friedmann M, Berg M, McVicar D W, Witthuhn B A, Silvennoinen O
Abstract excerpt
Interleukin-2 (IL-2) signaling requires the dimerization of the IL-2 receptor beta.(IL-2R beta) and common gamma (gamma c) chains. Mutations of gamma c can result in X-linked severe combined immunodeficiency (XSCID). IL-2, IL-4, IL-7 (whose receptors are known to contain gamma c), and IL-9 (whose receptor is shown here to contain gamma c) induced the tyrosine phosphorylation and activation of the Janus family...
Topics
- Animals
- Cell Line
- Enzyme Activation
- Humans
- Interleukin-2
- Janus Kinase 1
- Janus Kinase 3
- Mutation
- Phosphorylation
- Point Mutation
- Protein-Tyrosine Kinases