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Article

Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors.

Science (New York, N.Y.) - 18 Nov 2005

Wang Xinquan, Rickert Mathias, Garcia K Christopher

Abstract excerpt

Interleukin-2 (IL-2) is an immunoregulatory cytokine that acts through a quaternary receptor signaling complex containing alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gc) receptors. In the structure of the quaternary ectodomain complex as visualized at a resolution of 2.3 angstroms, the binding of IL-2Ralpha to IL-2 stabilizes a secondary binding site for presentation to IL-2Rbeta. gammac is then...

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PMID: 16293754
DOI: 10.1126/science.1117893

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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