Ligand binding by the IL-2 receptor is modulated by intracellular determinants of the IL-2 receptor beta-chain.

Article

Ligand binding by the IL-2 receptor is modulated by intracellular determinants of the IL-2 receptor beta-chain.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 1995

Goldsmith M A, Amaral M C, Greene W C

Abstract excerpt

The biologic actions of IL-2 are mediated by the IL-2R, a multisubunit receptor complex displayed on the surface of lymphocytes and select other hematopoietic lineages. The IL-2R exhibits multiple affinities for IL-2 that result from the monomeric (alpha), heterodimeric (alpha beta and beta gamma...

Topics

Animals
Binding Sites
Cell Line
Cell Membrane
Chlorocebus aethiops
Cytoplasm
Interleukin-2
Kinetics
Ligands
Mutation
Protein Conformation
Receptors, Interleukin-2
Transfection

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