Control of multiple autoantibodies linked with a lupus nephritis susceptibility locus in New Zealand black mice.

Article

Control of multiple autoantibodies linked with a lupus nephritis susceptibility locus in New Zealand black mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 1997

Vyse T J, Rozzo S J, Drake C G, Izui S, Kotzin B L

Abstract excerpt

An NZB locus on distal chromosome 1 has been linked to murine lupus nephritis in backcross analyses of New Zealand mice. This locus, designated Nba2 for New Zealand Black autoimmunity 2, was found to colocalize in both (NZB x SM/J)F1 x NZW and (B6.H2z x NZB)F1 x NZB backcrosses, and was most like...

Topics

Animals
Autoantibodies
Disease Susceptibility
Genetic Linkage
Genetic Predisposition to Disease
Lupus Nephritis
Mice

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