Article
Mapping of a gene for hypergammaglobulinemia to the distal region on chromosome 4 in NZB mice and its contribution to systemic lupus erythematosus in (NZB x NZW)F1 mice.
International immunology - 1 Dec 1994
Hirose S, Tsurui H, Nishimura H, Jiang Y, Shirai T
Abstract excerpt
IgM class hypergammaglobulinemia develops spontaneously in the early life of NZB mice. To determine the chromosomal location of the NZB gene(s) linked to this hypergammaglobulinemia and possible contribution to systemic lupus erythematosus (SLE)-like autoimmune disease observed in (NZB x NZW)F1 hybrid mice, we examined (NZB x NZW)F1 x NZW backcross mice, using a mapping technique based on polymorphism in simple...
Topics
- Animals
- Antibodies, Antinuclear
- Chromosome Mapping
- Female
- Genotype
- Hypergammaglobulinemia
- Immunoglobulin M
- Lupus Erythematosus, Systemic
- Mice
- Mice, Inbred NZB
- Mice, Inbred Strains