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Article

Functional dissection of lupus susceptibility loci on the New Zealand black mouse chromosome 1: evidence for independent genetic loci affecting T and B cell activation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2003

Wither Joan E, Lajoie Ginette, Heinrichs Svinda, Cai Yong-Chun, Chang Nan, Ciofani Amelia, Cheung Yui-Ho, MacLeod Ralph

Abstract excerpt

In previous work, we demonstrated linkage between a broad region on New Zealand Black (NZB) chromosome 1 and increased costimulatory molecule expression on B cells and autoantibody production. In this study, we produced C57BL/6 congenic mice with homozygous NZB chromosome 1 intervals of differing lengths. We show that both B6.NZBc1(35-106) (numbers denote chromosomal interval length) and B6.NZBc1(85-106) mice...

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PMID: 12902468
DOI: 10.4049/jimmunol.171.4.1697

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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