Article
The CCG1/TAFII250 gene is mutated in thermosensitive G1 mutants of the BHK21 cell line derived from golden hamster.
Gene - 20 Apr 1994
Hayashida T, Sekiguchi T, Noguchi E, Sunamoto H, Ohba T, Nishimoto T
Abstract excerpt
The CCG1 cDNA encoding a general transcription factor, TAFII250, complements a thermosensitive (ts) cell cycle mutant, tsBN462, of the BHK21 cell line, which arrests in the G1 phase at the restrictive temperature. In order to clarify whether the CCG1 is mutated in tsBN462 cells or a suppressor of tsBN462 mutation, CCG1 cDNAs isolated from parental wild-type (wt) BHK21 and tsBN462 cell lines were sequenced....
Topics
- Amino Acid Sequence
- Animals
- Cell Line
- Cricetinae
- DNA-Binding Proteins
- Histone Acetyltransferases
- Hot Temperature
- Mesocricetus
- Molecular Sequence Data
- Mutation
- Nuclear Proteins