Article
A single-point mutation in HCF causes temperature-sensitive cell-cycle arrest and disrupts VP16 function.
Genes & development - 15 Mar 1997
Goto H, Motomura S, Wilson A C, Freiman R N, Nakabeppu Y, Fukushima K, Fujishima M, Herr W, Nishimoto T
Abstract excerpt
The temperature-sensitive BHK21 hamster cell line tsBN67 ceases to proliferate at the nonpermissive temperature after a lag of one to a few cell divisions, and the arrested cells display a gene expression pattern similar to that of serum-starved cells. The temperature-sensitive phenotype is rever...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Cycle
- Cell Line
- Conserved Sequence
- Cricetinae
- DNA
- DNA-Binding Proteins
- Genes, Immediate-Early
- HeLa Cells
- Herpes Simplex Virus Protein Vmw65
- Homeodomain Proteins
- Host Cell Factor C1
- Humans