Article
Mutation of the hamster cell cycle gene RCC1 is complemented by the homologous genes of Drosophila and S.cerevisiae.
The EMBO journal - 1 May 1991
Ohtsubo M, Yoshida T, Seino H, Nishitani H, Clark K L, Sprague G F, Frasch M, Nishimoto T
Abstract excerpt
The RCC1 gene has been isolated from several vertebrates, including human, hamster and Xenopus. Genes similar to RCC1, namely BJ1 and SRM1/PRP20, have been isolated from the insect Drosophila and from the budding yeast Saccharomyces cerevisiae. A mutation of the RCC1 gene in the hamster BHK21 cell line, tsBN2, confers pleiotropic phenotypes, including G1 arrest and premature induction of mitosis in cells...
Topics
- Amino Acid Sequence
- Animals
- Cell Cycle
- Cell Line
- Cricetinae
- DNA-Binding Proteins
- Drosophila
- Fungal Proteins
- Gene Expression
- Genes, Regulator
- Guanine Nucleotide Exchange Factors