Article
The gene complementing a temperature-sensitive cell cycle mutant of BHK cells is the human homologue of the yeast RPC53 gene, which encodes a subunit of RNA polymerase C (III).
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Jun 1993
Ittmann M, Ali J, Greco A, Basilico C
Abstract excerpt
The temperature-sensitive BN51 cell cycle mutant of BHK cells arrests in G1 at the nonpermissive temperature (39.5 degrees C). We have previously reported cloning the gene which complements this mutation. The complementing gene encodes a highly charged protein with a basic amino-terminal domain a...
Topics
- Amino Acid Sequence
- Animals
- Chlorocebus aethiops
- Cricetinae
- Fibroblasts
- Fungal Proteins
- Genes
- Genes, Fungal
- Genetic Complementation Test
- Humans
- Interphase
- Kidney
- Mesocricetus
- Molecular Sequence Data
- Mutation