Inhibition of generation of authentic genomic termini of herpes simplex virus type 1 DNA in temperature-sensitive mutant BHK-21 cells with a mutated CCG1/TAF(II)250 gene.

Abstract excerpt

A temperature-sensitive (ts) mutant from the BHK-21 hamster cell line, tsBN462, has a defect in progression of the G1 phase at the nonpermissive temperature of 39.5 degrees C. The ts mutation in tsBN462 is located in the CCG1 gene, encoding the general transcription factor TAF(II)250. In tsBN462...

Topics

• Animals
• Cell Line
• Cricetinae
• DNA Replication
• DNA, Viral
• DNA-Binding Proteins
• Electrophoresis, Agar Gel
• Herpesvirus 1, Human
• Histone Acetyltransferases
• Humans
• Mutation
• Nuclear Proteins
• RNA, Messenger
• TATA-Binding Protein Associated Factors
• Temperature
• Trans-Activators
• Transcription Factor TFIID
• Virus Replication