Article
Accelerated caffeine metabolism after omeprazole treatment is indicated by urinary metabolite ratios: coincidence with plasma clearance and breath test.
Clinical pharmacology and therapeutics - 1 Apr 1994
Rost K L, Roots I
Abstract excerpt
BACKGROUND: Omeprazole has previously been shown to induce hepatic cytochrome P4501A2 activity, as evidenced by an accelerated N-3-demethylation in the 13C-[N-3-methyl]-caffeine breath test. In this study we investigated whether the inducing potency of omeprazole can be quantified by the determin...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Breath Tests
- Caffeine
- Chromatography, High Pressure Liquid
- Cytochrome P-450 CYP1A2
- Cytochrome P-450 Enzyme System
- Enzyme Induction
- Female
- Humans
- Male
- Mephenytoin
- Middle Aged
- Omeprazole
- Oxidoreductases, N-Demethylating
- Phenotype