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Article

Inducibility of CYP1A2 by omeprazole in vivo related to the genetic polymorphism of CYP1A2.

British journal of clinical pharmacology - 1 Nov 2002

Han Xing-Mei, Ouyang Dong-Sheng, Chen Xiao-Ping, Shu Yan, Jiang Chang-Hong, Tan Zhi-Rong, Zhou Hong-Hao

Abstract excerpt

AIMS: To evaluate the effect of the CYP1A2*1C and CYP1A2*1F polymorphisms on the inducibility of CYP1A2 by omeprazole in healthy subjects. METHODS: Mutations of CYP2C19 and CYP1A2 were identified by PCR-RFLP. Omeprazole, 120 mg day-1, was given to 12 extensive metabolizers (EM) with respect to CYP2C19 (six CYP1A2*1F/CYP1A2*1F and six CYP1A2*1C/CYP1A2*1F of CYP1A2) for 7 days. CYP1A2 activity was determined on...

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Identifiers

PMID: 12445035
DOI: 10.1046/j.1365-2125.2002.01686.x
PMCID: PMC1874453

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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