Article
Increase of cytochrome P450IA2 activity by omeprazole: evidence by the 13C-[N-3-methyl]-caffeine breath test in poor and extensive metabolizers of S-mephenytoin.
Clinical pharmacology and therapeutics - 1 Aug 1992
Rost K L, Brösicke H, Brockmöller J, Scheffler M, Helge H, Roots I
Abstract excerpt
Omeprazole has been shown to induce cytochrome P450IA1 and P450IA2 activity in vitro. To reflect cytochrome P450IA2 (CYP1A2) activity in vivo, the 13C-[N-3-methyl]-caffeine breath test was conducted in 18 volunteers: 12 extensive metabolizers, one intermediate metabolizer, and five poor metaboliz...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Aryl Hydrocarbon Hydroxylases
- Breath Tests
- Caffeine
- Carbon Dioxide
- Carbon Isotopes
- Cytochrome P-450 CYP1A2
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 Enzyme System
- Dose-Response Relationship, Drug
- Enzyme Induction
- Female
- Humans
- Male
- Mephenytoin