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Article

Application of Microdosed Intravenous Omeprazole to Determine Hepatic CYP2C19 Activity.

Journal of clinical pharmacology - 1 Jun 2021

Mahmoudi Mazyar, Foerster Kathrin I, Burhenne Jürgen, Weiss Johanna, Mikus Gerd, Haefeli Walter E

Abstract excerpt

Omeprazole is an established probe drug to assess cytochrome P450 (CYP) 2C19 activity (phenotyping). Because it has nonlinear pharmacokinetics (PK) after oral administration (autoinhibition of metabolism), the true impact of coadministered perpetrators on CYP2C19 substrates might be underestimated after regular doses. We tested the dose linearity of an intravenous omeprazole microdose of 100 µg and compared it...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33236774
DOI: 10.1002/jcph.1789

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