Article
p53 gene mutations inside and outside of exons 5-8: the patterns differ in breast and other cancers.
Oncogene - 16 Feb 1995
Hartmann A, Blaszyk H, McGovern R M, Schroeder J J, Cunningham J, De Vries E M, Kovach J S, Sommer S S
Abstract excerpt
Most studies of mutations in the p53 tumor suppressor gene in tumors have examined only exons 5-8. Our laboratory previously found 64 mutations in exons 5-8 of the p53 gene in 194 primary breast cancers. Herein, we report 18 additional mutations found outside of exons 5-8. Mutations are present in exons 4, 9 and 10, and flanking splice junctions, but not in the promotor region or in exons 1, 2, 3 and 11. No...
Topics
- Adult
- Aged
- Base Sequence
- Breast Neoplasms
- DNA Primers
- Exons
- Female
- Genes, p53
- Humans
- Liver Neoplasms
- Lung Neoplasms
- Middle Aged