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Article

Wild-type human p53 activates the human epidermal growth factor receptor promoter.

Oncogene - 1 May 1994

Deb S P, Muñoz R M, Brown D R, Subler M A, Deb S

Abstract excerpt

We show that wild-type human p53 transactivates the human epidermal growth factor receptor (EGFR) promoter in vivo in a dose-dependent manner, implicating p53 in promotion of cell proliferation. This activation is sensitive to the expression of cellular oncoprotein MDM2 and human papillomavirus type 18 (HPV-18) E6 protein. The p53 response element is localized within -15 and -569 of the promoter. The EGFR...

Topics

Base Sequence
Binding Sites
Cells, Cultured
Chloramphenicol O-Acetyltransferase
ErbB Receptors
Gene Expression Regulation
Genes, p53
Humans
Molecular Sequence Data
Mutation
Promoter Regions, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8152794

Genes

EGFR
MDM2
TBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8152794-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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