Article
Distinct regions of p53 have a differential role in transcriptional activation and repression functions.
Oncogene - 1 Mar 1994
Sang B C, Chen J Y, Minna J, Barbosa M S
Abstract excerpt
The wild type p53 tumor suppressor protein transactivates genes carrying p53 responsive elements and represses several TATA containing promoters. We report in vivo gene regulation assays where deletion of the N-terminal 75 residues (delta N75) results in loss of transactivation of p53CON and repression of an HPV 6 reporter. In contrast, removal of the C-terminal 75 (delta C75) amino acids resulted in a truncated...
Topics
- Base Sequence
- Cloning, Molecular
- Gene Expression Regulation
- Humans
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Peptide Fragments
- Sequence Deletion
- Transcription, Genetic
- Transcriptional Activation