Article
The tumor suppressor protein p53 strongly alters human immunodeficiency virus type 1 replication.
Journal of virology - 1 Jul 1994
Duan L, Ozaki I, Oakes J W, Taylor J P, Khalili K, Pomerantz R J
Abstract excerpt
The p53 tumor suppressor gene product, a sequence-specific DNA-binding protein, has been shown to act as a transcriptional activator and repressor both in vitro and in vivo. Consistent with its role in regulating transcription are recent observations that the N-terminal acidic domain of p53 binds directly to the TATA box-binding protein subunit of the general transcription factor, TF IID. It is now demonstrated...
Topics
- Base Sequence
- Cells, Cultured
- DNA Primers
- Down-Regulation
- Escherichia coli
- Genetic Vectors
- HIV Long Terminal Repeat
- HIV-1
- Humans
- Molecular Sequence Data
- Mutation