Article
Mutant human tumor suppressor p53 modulates the activation of mitogen-activated protein kinase and nuclear factor-kappaB, but not c-Jun N-terminal kinase and activated protein-1.
Molecular carcinogenesis - 1 Jan 2006
Gulati Anthony P, Yang Yang-Ming, Harter David, Mukhopadhyay Asok, Aggarwal Bharat B, Aggarwal Bharat A, Benzil Deborah L, Whysner John, Albino Anthony P, Murali Raj, Jhanwar-Uniyal Meena
Abstract excerpt
The roles of the mitogen-activated kinase protein (MAPK) pathway, nuclear factor-kappa B (NF-kappaB), and activator protein-1 (AP-1) in cellular responses to growth factors and mitogen are well established. However, the manner by which these proliferative pathways are affected by the tumor suppressor protein p53 is not fully understood. We report here the results of an investigation of the status of p53 on two...
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