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Article

Transcriptional Activation of the Human Epidermal Growth Factor Receptor Promoter by Human p53

1 Nov 1996

Abstract excerpt

The human epidermal growth factor receptor (EGFR) promoter is activated by both wild-type and tumor-derived mutant p53. In this communication, we demonstrate that EGFR promoter sequence requirements for transactivation by wild-type and mutant p53 are different. Transient-expression assays with EGFR promoter deletions identified a wild-type human p53 response element, 5'-AGCTAGACGTCCGGGCAGCCCCCGGCG -3', from...

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Identifiers

PMID: 8887630
DOI: 10.1128/mcb.16.11.6009

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Transcriptional Activation of the Human Epidermal Growth Factor Receptor Promoter by Human p53PMID 8887630Read ↗

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