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Repression of RNA Polymerase I Transcription by the Tumor Suppressor p53

1 Aug 2000

Abstract excerpt

The tumor suppressor protein p53 is frequently inactivated in tumors. It functions as a transcriptional activator as well as a repressor for a number of viral and cellular promoters transcribed by RNA polymerase II (Pol II) and by RNA Pol III. Moreover, it appears that p53 also suppresses RNA Pol I transcription. In this study, we examined the molecular mechanism of Pol I transcriptional inhibition by p53. We...

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Identifiers

PMID: 10913176
DOI: 10.1128/mcb.20.16.5930-5938.2000

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