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Article

Regulation of insulin-like growth factor II P3 promotor by p53: a potential mechanism for tumorigenesis.

Cancer research - 15 Mar 1996

Zhang L, Kashanchi F, Zhan Q, Zhan S, Brady J N, Fornace A J, Seth P, Helman L J

Abstract excerpt

Human insulin-like growth factor (IGF)-II mRNA has been shown to be expressed at high levels in a variety of tumors, including rhabdomyosarcomas. In addition, many tumors have alterations in p53 expression. To investigate whether p53 regulates IGF-II gene expression, we transfected wild-type p53 expression vectors and luciferase constructs driven by IGF-II P3 promotors into multiple cell lines. We found that p53...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 8640827

Genes

CCL13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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