The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein.

doi:10.1002/j.1460-2075.1992.tb05608.x

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Article

The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein.

The EMBO journal - 1 Dec 1992

Mietz J A, Unger T, Huibregtse J M, Howley P M

Abstract excerpt

The observed interaction between p53 and the oncoproteins encoded by several DNA tumor viruses suggests that these viruses mediate their transforming activities at least in part by altering the normal growth regulatory function of p53. In this study we examined the effect of viral oncoprotein expression on the transcriptional transactivation function of wild-type p53 in human cells. Plasmids expressing human p53...

Topics

Antigens, Polyomavirus Transforming
Base Sequence
Blotting, Western
Chloramphenicol O-Acetyltransferase
DNA, Single-Stranded
Humans
Molecular Sequence Data
Mutation
Oncogene Proteins, Viral
Plasmids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein-Tyrosine Kinases

Repressor Proteins

Transcription, Genetic

Transcriptional Activation

Transfection

Tumor Cells, Cultured

Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 1464323
DOI: 10.1002/j.1460-2075.1992.tb05608.x
PMCID: PMC556979

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1464323-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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