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Article

Loss of p53 induces epidermal growth factor receptor promoter activity in normal human keratinocytes.

Oncogene - 17 Jul 2008

Bheda A, Creek K E, Pirisi L

Abstract excerpt

Overexpression of the epidermal growth factor receptor (EGFR) in human papillomavirus type 16-immortalized human keratinocytes (HKc) is caused by the viral oncoprotein E6, which targets p53 for degradation. We have previously observed that expression of p53 RNAi in normal HKc is associated with an increase in EGFR mRNA and protein. We now report that p53 RNAi induces EGFR promoter activity up to approximately...

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Source

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Identifiers

PMID: 18391986
DOI: 10.1038/onc.2008.65
PMCID: PMC2572188

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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