Article
Abnormal structure and expression of the p53 gene in human ovarian carcinoma cell lines.
Cancer research - 1 Aug 1992
Yaginuma Y, Westphal H
Abstract excerpt
In an effort to analyze molecular mechanisms of human ovarian carcinogenesis, we studied the structure and expression of the p53 gene in different cell lines established from human ovarian carcinomas. In all six lines (PA-1, Caov-3 and -4, OVCAR-3, SK-OV-3, and Kuramochi), p53 abnormalities were detected. In the SK-OV-3 cell line, Southern analysis suggested the presence of sequence deletions/rearrangements in at...
Topics
- Base Sequence
- Blotting, Southern
- Cell Line
- Cloning, Molecular
- DNA
- DNA, Neoplasm
- Female
- Gene Expression
- Genes, p53
- Humans
- Molecular Sequence Data
- Mutation