Binding and repression of the latency-associated promoter of herpes simplex virus by the immediate early 175K protein.

doi:10.1099/0022-1317-75-4-753

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Article

Binding and repression of the latency-associated promoter of herpes simplex virus by the immediate early 175K protein.

The Journal of general virology - 1 Apr 1994

Batchelor A H, Wilcox K W, O'Hare P

Abstract excerpt

We demonstrate that the immediate early 175K protein (IE175K) of herpes simplex virus type 1 binds to the cap site of the latency-associated promoter (LAP) in an unusual manner. The complex formed on the LAP cap site was significantly larger than that formed on the IE175K cap site and the require...

Topics

Antibodies, Monoclonal
Base Sequence
Binding, Competitive
Consensus Sequence
DNA Probes
DNA, Viral
DNA-Binding Proteins
Gene Expression Regulation, Viral
HeLa Cells
Herpesvirus 1, Human
Humans
Immediate-Early Proteins
Kinetics
Models, Genetic
Molecular Sequence Data
Mutation
Promoter Regions, Genetic
Protein Binding

Source

Open in PubMed

Identifiers

PMID: 8151293
DOI: 10.1099/0022-1317-75-4-753

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8151293-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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