Article
Analysis of the promoter and cis-acting elements regulating expression of herpes simplex virus type 2 latency-associated transcripts.
Journal of virology - 1 May 1995
Wang K, Krause P R, Straus S E
Abstract excerpt
In latently infected neurons, herpes simplex virus type 2 (HSV-2) expresses one abundant family of transcripts, the latency-associated transcripts (LATs). We demonstrate here that the sequence lying about 700 bp upstream of the 5' end of the HSV-2 major LAT acts as a very strong promoter in trans...
Topics
- Animals
- Base Sequence
- Cell Line
- DNA, Viral
- Gene Expression Regulation, Viral
- Genes, Viral
- HeLa Cells
- Herpesvirus 2, Human
- Humans
- Mice
- Molecular Sequence Data
- Mutation
- Neurons
- PC12 Cells
- Promoter Regions, Genetic
- Rats
- TATA Box
- Transcription, Genetic