Article
The major transcriptional regulatory protein of herpes simplex virus type 1 includes a protease resistant DNA binding domain.
Nucleic acids research - 11 Aug 1990
Everett R D, Paterson T, Elliott M
Abstract excerpt
Herpes simplex virus type 1 expresses five immediate-early (IE) polypeptides. In the absence of functional Vmw175 (the product of IE gene 3) activation of transcription of later classes of viral genes and repression of IE gene expression does not occur. The recognition of specific DNA sequences by Vmw175 requires, as determined by sensitivity to mutation, a part of the protein highly conserved in the...
Topics
- DNA, Viral
- DNA-Binding Proteins
- Endopeptidase K
- Gene Expression Regulation, Viral
- HeLa Cells
- Humans
- Mutation
- Serine Endopeptidases
- Simplexvirus
- Transcription Factors