Article
A mutant of herpes simplex virus type 1 immediate early polypeptide Vmw175 binds to the cap site of its own promoter in vitro but fails to autoregulate in vivo.
The Journal of general virology - 1 Apr 1990
Paterson T, Preston V G, Everett R D
Abstract excerpt
Vmw175, the product of herpes simplex virus type 1 immediate early (IE) gene 3, is essential for viral replication. It is required for the activation of transcription from both early and late gene promoters and also for the repression of IE gene expression. Vmw175 is able to bind specifically to...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Line
- DNA Mutational Analysis
- DNA, Viral
- DNA-Binding Proteins
- Gene Expression Regulation, Viral
- Immediate-Early Proteins
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Restriction Mapping
- Simplexvirus
- Temperature
- Transcription, Genetic
- Ubiquitin-Protein Ligases
- Viral Proteins