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Article

Immediate-early expression of the herpes simplex virus type 1 ICP27 transcript is not critical for efficient replication in vitro or in vivo.

Journal of virology - 1 Oct 2004

Sun Aixu, Devi-Rao G V, Rice M K, Gary L W, Bloom D C, Sandri-Goldin R M, Ghazal P, Wagner E K

Abstract excerpt

We constructed a promoter mutation altering the immediate-early expression of the herpes simplex virus type 1 (HSV-1) ICP27 transcript and its cognate wild-type rescue viruses in order to assess the role of the ICP27 protein in the earliest stages of viral infection by global transcriptional analysis with a DNA microarray. This mutant, ICP27/VP16, replaces the whole ICP27 promoter/enhancer with the VP16 promoter....

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Source

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Identifiers

PMID: 15367613
DOI: 10.1128/JVI.78.19.10470-10478.2004
PMCID: PMC516393

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Immediate-early expression of the herpes simplex virus type 1 ICP27 transcript is not critical for efficient replication in vitro or in vivo.PMID 15367613Read ↗

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