Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Shuttling of the herpes simplex virus type 1 regulatory protein ICP27 between the nucleus and cytoplasm mediates the expression of late proteins.

Journal of virology - 1 Dec 1997

Soliman T M, Sandri-Goldin R M, Silverstein S J

Abstract excerpt

The herpes simplex virus type 1 (HSV-1) immediate-early protein ICP27 is required posttranscriptionally for the expression of HSV-1 late genes during a productive infection. ICP27 also inhibits host cell pre-mRNA splicing, effectively shutting off host cell protein synthesis. Here we describe intragenic suppressors of LG4, a virus with a conditional lethal mutation in the gene encoding ICP27. At the restrictive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Nucleus
Share to Chlorocebus aethiops

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytoplasm

Share to Gene Expression Regulation, Viral

Share to Genes, Viral

Share to Phenotype

Share to RNA, Viral

Share to Viral Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 9371577
DOI: 10.1128/JVI.71.12.9188-9197.1997
PMCID: PMC230221

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Shuttling of the herpes simplex virus type 1 regulatory protein ICP27 between the nucleus and cytoplasm mediates the expression of late proteins.PMID 9371577Read ↗

Evidence that the herpes simplex virus immediate early protein ICP27 acts post-transcriptionally during infection to regulate gene expression.Semantic proximity Read ↗

The herpes simplex virus ICP27 protein: a multifunctional post-transcriptional regulator of gene expressionSemantic proximity Read ↗

The many roles of the regulatory protein ICP27 during herpes simplex virus infectionSemantic proximity Read ↗

The herpes simplex virus regulatory protein ICP27 contributes to the decrease in cellular mRNA levels during infectionSemantic proximity Read ↗

Herpes simplex virus inhibits host cell splicing, and regulatory protein ICP27 is required for this effectSemantic proximity Read ↗

Intracellular localization of the herpes simplex virus type 1 major transcriptional regulatory protein, ICP4, is affected by ICP27.Semantic proximity Read ↗

Identification of herpes simplex virus RNAs that interact specifically with regulatory protein ICP27 in vivo.Semantic proximity Read ↗

The Herpes Simplex Virus Immediate-Early Protein ICP27 Shuttles between Nucleus and CytoplasmSemantic proximity Read ↗

Herpes simplex virus blocks host transcription termination via the bimodal activities of ICP27Semantic proximity Read ↗

Herpes simplex virus 1 ICP27 is required for transcription of two viral late (gamma 2) genes in infected cells.Semantic proximity Read ↗

Identification of an export control sequence and a requirement for the KH domains in ICP27 from herpes simplex virus type 1.Semantic proximity Read ↗

The Many Roles of the Highly Interactive HSV Protein ICP27, A Key Regulator of InfectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.