Mutations in the alpha 1 domain of a class I gene define residues important for specific allorecognition.

doi:10.1016/0008-8749(90)90020-r

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Article

Mutations in the alpha 1 domain of a class I gene define residues important for specific allorecognition.

Cellular immunology - 1 Jun 1990

Murray R, Katoh K, Alexander J, Muller D, Pederson K, Frelinger J A

Abstract excerpt

Our strategy to use saturation mutagenesis to produce an unbiased collection of major histocompatibility class I mutants has resulted in unpredicted mutant phenotypes. First, we have shown data supporting our earlier work of the Dp20(Y27N) mutant. Allorecognition is altered at the clonal level wh...

Topics

Animals
Antibodies, Monoclonal
Cytotoxicity, Immunologic
Electrophoresis, Gel, Two-Dimensional
Epitopes
H-2 Antigens
Hypersensitivity, Delayed
Lymphocyte Activation
Lymphocytic choriomeningitis virus
Macromolecular Substances
Mice
Mutation
T-Lymphocytes
beta 2-Microglobulin

Source

Open in PubMed

Identifiers

PMID: 1693100
DOI: 10.1016/0008-8749(90)90020-r

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1693100-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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