Conserved amino acid residues in the complementarity-determining region 1 of the TCR beta-chain are involved in the recognition of conventional Ag and Mls-1 superantigen.

Abstract excerpt

Superantigens activate T cells by interacting primarily with the V beta region of the TCR. This report describes a series of studies performed to elucidate the role of the conserved amino acid motif (Asp-His-Asn) in the complementarity-determining region 1 (CDR1) of the TCR V beta chains that recognize murine endogenous superantigen Mls-1. By using site-directed mutagenesis of the Mls-1-reactive TCR V beta 6...

Topics

• Amino Acid Sequence
• Animals
• Antigens
• CD4 Antigens
• Cell Line
• Conserved Sequence
• Mice
• Mice, Inbred C57BL
• Mice, Inbred DBA
• Minor Lymphocyte Stimulatory Antigens
• Molecular Sequence Data