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Article

Analysis of the interaction site for the self superantigen Mls-1a on T cell receptor V beta.

The Journal of experimental medicine - 1 May 1991

Pullen A M, Bill J, Kubo R T, Marrack P, Kappler J W

Abstract excerpt

Superantigen bound to major histocompatibility complex (MHC) products have been shown to stimulate T cells in a V beta-specific manner. Mouse T cells bearing V beta 8.1 usually respond to the self superantigen, Mls-1a, whereas T cells bearing V beta 8.2a do not. Previously, using site-directed mutational analysis, we identified the residues of natural variants of T cell receptor (TCR) V beta 8.2 that conferred...

Topics

Animals
Antigens, Surface
Carbohydrates
Cell Line
Glycosylation
Immunoglobulin Variable Region
Major Histocompatibility Complex
Mice
Minor Lymphocyte Stimulatory Antigens
Mutation
Precipitin Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Antigen, T-Cell

T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 1902503
DOI: 10.1084/jem.173.5.1183
PMCID: PMC2118855

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1902503-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Analysis of the interaction site for the self superantigen Mls-1a on T cell receptor V beta.PMID 1902503Read ↗

Identification of the region of T cell receptor beta chain that interacts with the self-superantigen MIs-1a.Semantic proximity Read ↗

Conserved amino acid residues in the complementarity-determining region 1 of the TCR beta-chain are involved in the recognition of conventional Ag and Mls-1 superantigen.Semantic proximity Read ↗

Superantigens interact with MHC class II molecules outside of the antigen groove.Semantic proximity Read ↗

Mouse mammary tumor virus superantigens require N-linked glycosylation for effective presentation to T cells.Semantic proximity Read ↗

Presentation of the Mls-1 superantigen by human HLA class II molecules to murine T cells.Semantic proximity Read ↗

Recognition of a single amino acid change on the surface of a major transplantation antigen is in the context of self peptide.Semantic proximity Read ↗

Association of mouse mammary tumor virus superantigen with MHC class II during biosynthesis.Semantic proximity Read ↗

Identification of class II major histocompatibility complex and T cell receptor binding sites in the superantigen toxic shock syndrome toxin 1.Semantic proximity Read ↗

T cell receptor interaction with peptide/major histocompatibility complex (MHC) and superantigen/MHC ligands is dominated by antigen.Semantic proximity Read ↗

Direct evidence for the role of COOH terminus of mouse mammary tumor virus superantigen in determining T cell receptor V beta specificity.Semantic proximity Read ↗

The V beta complementarity determining region 1 of a major histocompatibility complex (MHC) class I-restricted T cell receptor is involved in the recognition of peptide/MHC I and superantigen/MHC II complex.Semantic proximity Read ↗

The open reading frames in the 3' long terminal repeats of several mouse mammary tumor virus integrants encode V beta 3-specific superantigens.Semantic proximity Read ↗

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