Article
A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway.
Nature - 1 Jan 2000
Spies T, Bresnahan M, Bahram S, Arnold D, Blanck G, Mellins E, Pious D, DeMars R
Abstract excerpt
Major histocompatibility complex (MHC) class I molecules export peptides to the cell surface for surveillance by cytotoxic T lymphocytes. Intracellular peptide binding is critical for the proper assembly and transport of class I molecules. This mechanism is impaired as a result of a non-functiona...
Topics
- Amino Acid Sequence
- Antigen-Presenting Cells
- B-Lymphocytes
- Base Sequence
- Biological Transport, Active
- Carrier Proteins
- Cell Line
- Chromosome Deletion
- Chromosome Mapping
- Cosmids
- DNA
- Deoxyribonucleases, Type II Site-Specific
- Histocompatibility Antigens Class I
- Histocompatibility Antigens Class II