Sodium phenobarbital-enhanced mutation frequency in the liver DNA of lacZ transgenic mice treated with diethylnitrosamine.

doi:10.1093/mutage/12.3.179

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Article

Sodium phenobarbital-enhanced mutation frequency in the liver DNA of lacZ transgenic mice treated with diethylnitrosamine.

Mutagenesis - 1 May 1997

Okada N, Honda A, Kawabata M, Yajima N

Abstract excerpt

To investigate how a carcinogenic promoter acts on cells mutated by an initiator, we used as a model, lacZ transgenic mouse and a positive selection system. Preliminary data for the mutational events in liver DNA of the mice was generated using diethylnitrosamine (DEN) and sodium phenobarbital (S...

Topics

Animals
Body Weight
Carcinogens
Cocarcinogenesis
DNA
Diethylnitrosamine
Drug Synergism
Lac Operon
Liver
Male
Mice
Mice, Transgenic
Mutagens
Mutation
Organ Size
Phenobarbital

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