Article
The tumour promoters dieldrin and phenobarbital increase the frequency of c-Ha-ras wild-type, but not of c-Ha-ras mutated focal liver lesions in male C3H/He mice.
Carcinogenesis - 1 Mar 1992
Bauer-Hofmann R, Buchmann A, Mahr J, Kress S, Schwarz M
Abstract excerpt
The frequency and pattern of mutations at codon 61 of the c-Ha-ras protooncogene were analysed in glucose-6-phosphatase-deficient hepatic lesions of male C3H/He mice occurring either spontaneously or after continuous treatment with 10 p.p.m. dieldrin or 500 p.p.m. phenobarbital (PB) in their diet...
Topics
- Amino Acid Sequence
- Animals
- Codon
- Dieldrin
- Genes, ras
- Glucose-6-Phosphatase
- Liver
- Liver Neoplasms
- Male
- Mice
- Mice, Inbred C3H
- Molecular Sequence Data
- Mutation
- Phenobarbital
- Polymerase Chain Reaction