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Article

Role of mutations at codon 61 of the c-Ha-ras gene during diethylnitrosamine-induced hepatocarcinogenesis in C3H/He mice.

Molecular carcinogenesis - 1 Jan 1992

Bauer-Hofmann R, Klimek F, Buchmann A, Müller O, Bannasch P, Schwarz M

Abstract excerpt

Liver tumors of certain strains of mice frequently contain mutations at codon 61 of the c-Ha-ras gene. In our study, we investigated the significance of these mutations in the carcinogenic process. Male C3H/He mice received a single injection of diethylnitrosamine (DEN) on day 15 after birth, and groups of animals were killed at various time intervals between 11 and 52 wk after treatment. At the earlier time...

Topics

Animals
Base Sequence
Cell Transformation, Neoplastic
DNA Mutational Analysis
Diethylnitrosamine
Genes, ras
Glucose-6-Phosphatase
Liver Neoplasms
Mice
Mice, Inbred C3H
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nucleic Acid Hybridization

Polymerase Chain Reaction

Source

Identifiers

PMID: 1323970
DOI: 10.1002/mc.2940060110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1323970-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Role of mutations at codon 61 of the c-Ha-ras gene during diethylnitrosamine-induced hepatocarcinogenesis in C3H/He mice.PMID 1323970Read ↗

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