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Article

HLA-DQ2 second-domain polymorphisms may explain increased trans-associated risk in celiac disease and dermatitis herpetiformis.

Human immunology - 1 Dec 1993

Hall M A, Lanchbury J S, Lee J S, Welsh K I, Ciclitira P J

Abstract excerpt

Sequence polymorphism in the DQ2 beta chain was investigated in 80 Caucasoid patients with CD, 23 patients with DH, and 64 healthy controls. A set of amplification primers were designed to amplify a 281-bp region between amino acids 95 and 135 encoding the second domain of the DQ beta chain gene....

Topics

Amino Acid Sequence
Base Sequence
Blotting, Southern
Celiac Disease
DNA, Complementary
Dermatitis Herpetiformis
Genotype
HLA-DQ Antigens
Humans
Molecular Sequence Data
Polymerase Chain Reaction
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8138424
DOI: 10.1016/0198-8859(93)90556-g

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8138424-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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HLA-DQ2 second-domain polymorphisms may explain increased trans-associated risk in celiac disease and dermatitis herpetiformis.PMID 8138424Read ↗

A collaborative European search for non-DQA1*05-DQB1*02 celiac disease loci on HLA-DR3 haplotypes: analysis of transmission from homozygous parents.Semantic proximity Read ↗

Reevaluation of the relative risk for susceptibility to celiac disease of HLA-DRB1, -DQA1, -DQB1, -DPB1, and -TAP2 alleles in a French population.Semantic proximity Read ↗

HLA-DR, DQ genotypes of celiac disease patients and healthy subjects from the West of Ireland.Semantic proximity Read ↗

Molecular characterization of HLA class II genes in celiac disease patients of Latin American Caucasian origin.Semantic proximity Read ↗

HLA association with dermatitis herpetiformis is accounted for by a cis or transassociated DQ heterodimer.Semantic proximity Read ↗

Additional factor in some HLA DR3/DQ2 haplotypes confers a fourfold increased genetic risk of celiac disease.Semantic proximity Read ↗

Structural and Functional Studies of trans-Encoded HLA-DQ2.3 (DQA1*03:01/DQB1*02:01) Protein MoleculeSemantic proximity Read ↗

HLA class II region genes and susceptibility to dermatitis herpetiformis: DPB1 and TAP2 associations are secondary to those of the DQ subregion.Semantic proximity Read ↗

Defining the contribution of the HLA region to cis DQ2-positive coeliac disease patients.Semantic proximity Read ↗

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