Additional factor in some HLA DR3/DQ2 haplotypes confers a fourfold increased genetic risk of celiac disease.

doi:10.1034/j.1399-0039.2003.00028.x

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Article

Additional factor in some HLA DR3/DQ2 haplotypes confers a fourfold increased genetic risk of celiac disease.

Tissue antigens - 1 Apr 2003

Bolognesi E, Karell K, Percopo S, Coto I, Greco L, Mantovani V, Suoraniemi E, Partanen J, Mustalahti K, Mäki M, Momigliano-Richiardi P

Abstract excerpt

Although HLA-DQ genes are the major celiac disease (CD) susceptibility genes, results from Finnish families suggest that not all DQ2-encoding haplotypes confer equal susceptibility to CD, implying the effect of other gene(s) in the HLA region. The aim of the present work was to extend and confirm the aforementioned results in a southern European population ( Italian) and to better localize the additional risk...

Topics

Celiac Disease
Finland
Genetic Markers
Genetic Predisposition to Disease
HLA-DQ Antigens
HLA-DR3 Antigen
Haplotypes
Humans
Italy

Source

Open in PubMed

Identifiers

PMID: 12753669
DOI: 10.1034/j.1399-0039.2003.00028.x

Genes

HFE
MICA
MICB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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