Article
A collaborative European search for non-DQA1*05-DQB1*02 celiac disease loci on HLA-DR3 haplotypes: analysis of transmission from homozygous parents.
Human immunology - 1 Mar 2003
Louka Andrew S, Moodie Simon J, Karell Kati, Bolognesi Elisabetta, Ascher Henry, Greco Luigi, Momigliano-Richiardi Patricia, Partanen Jukka, Ciclitira Paul J, Sollid Ludvig M
Abstract excerpt
The HLA-DQA1*05 with DQB1*02 alleles are a major risk factor for celiac disease (CD). To search for additional human leukocyte antigen (HLA) risk factors, we looked on the DR3-DQ2 risk haplotype, selected because it carries both DQ risk alleles in cis and is the more represented among CD patients. In a European consortium, we identified 109 families with a parent homozygous for DQA1*05-DQB1*02. We typed ten...
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