Genetic associations with human longevity at the APOE and ACE loci.

doi:10.1038/ng0194-29

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Article

Genetic associations with human longevity at the APOE and ACE loci.

Nature genetics - 1 Jan 1994

Schächter F, Faure-Delanef L, Guénot F, Rouger H, Froguel P, Lesueur-Ginot L, Cohen D

Abstract excerpt

In an effort to dissect the genetic components of longevity, we have undertaken case-control studies of populations of centenarians (n = 338) and adults aged 20-70 years at several polymorphic candidate gene loci. Here we report results on two genes, chosen for their impact on cardiovascular risk, encoding apolipoprotein E (ApoE), angiotensin-converting enzyme (ACE). We find that the epsilon 4 allele of APOE,...

Topics

Adult
Aged
Aged, 80 and over
Alleles
Apolipoproteins E
Base Sequence
Case-Control Studies
Female
France
Gene Frequency
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Longevity

Male

Middle Aged

Molecular Sequence Data

Peptidyl-Dipeptidase A

Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 8136829
DOI: 10.1038/ng0194-29

Genes

ACE
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8136829-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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