Article
Sex differences in the association of apolipoprotein E and angiotensin-converting enzyme gene polymorphisms with healthy aging and longevity: a population-based study from Southern Italy.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Sept 2006
Seripa Davide, Franceschi Marilisa, Matera Maria G, Panza Francesco, Kehoe Patrick G, Gravina Carolina, Orsitto Giuseppe, Solfrizzi Vincenzo, Di Minno Giovanni, Dallapiccola Bruno, Pilotto Alberto
Abstract excerpt
We investigated the association of sex and age with the occurrence of apolipoprotein E (apoE) and angiotensin-converting enzyme (ACE) genotypes in healthy aging and longevity in 1344 healthy individuals and 64 centenarians. As compared to participants younger than 60 years, a significant higher frequency of the apoE/epsilon2 was observed in men aged 60-90 years (p <.001) and in centenarians (p <.001). Logistic...
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