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Article

Methodological problems in genetic association studies of longevity--the apolipoprotein E gene as an example.

International journal of epidemiology - 1 Oct 2004

Lewis Sarah J, Brunner Eric J

Abstract excerpt

BACKGROUND: Cross-sectional genetic association studies are now widely employed to look for genes which confer longevity. Such studies are based on two assumptions; (a) initial relative allele frequencies in the different age cohorts are similar, and (b) the risk of mortality conferred by genotypes does not depend on year of birth. METHODS: We explored the validity of these assumptions and reviewed 15...

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Source

Identifiers

PMID: 15319409
DOI: 10.1093/ije/dyh214

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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