Article
The efficiency of genetic analysis of DNA from aged siblings to detect chromosomal regions implicated in longevity.
Mechanisms of ageing and development - 20 Oct 2000
Nemani M, Sahbatou M, Blanché H, Thomas G, Pascoe L
Abstract excerpt
Studies of the frequencies of different alleles in young adults and aged individuals have implicated several genes, such as ApoE and ACE, in longevity. However such association studies can easily give rise to spurious results through unsuspected population subdivision, and an approach making use of genetic relationships among relatives is desirable. We have studied the effectiveness of non-parametric genetic...
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