Article
Lower prevalence of epsilon 4 allele of apolipoprotein E gene in healthy, longer-lived individuals of Hellenic origin.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Dec 2006
Stakias Nikolaos, Liakos Panagiotis, Tsiapali Efthimia, Goutou Maria, Koukoulis Georgios N
Abstract excerpt
Apolipoprotein E (ApoE), and especially its epsilon4 isoform, is considered a risk factor predisposing to coronary heart disease. We hypothesized that the absence of epsilon4 allele offers a better chance for longer life. So we compared the prevalence of ApoE genotypes in 80 healthy aged individuals (HAI) (>80 years) and 391 Greek adults (median age 43 years) with ApoE genotype distribution consistent with the...
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