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Article

Analysis of duplex DNA by triple helix formation: application to detection of a p53 microdeletion.

BioTechniques - 1 Jan 1994

Olivas W M, Maher L J

Abstract excerpt

Conventional methods for mutation detection include Southern hybridization, direct sequencing of PCR products and single-strand conformation polymorphism analysis. We present an additional screening method that employs oligonucleotide-directed DNA triple helix formation to detect mutations within homopurine sequences. The proposed strategy is simple and may be of particular value when screening many DNA samples...

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PMID: 8136126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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