Analyzing and comparing nucleic acid sequences by hybridization to arrays of oligonucleotides: evaluation using experimental models.

doi:10.1016/0888-7543(92)90014-j

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Article

Analyzing and comparing nucleic acid sequences by hybridization to arrays of oligonucleotides: evaluation using experimental models.

Genomics - 1 Aug 1992

Southern E M, Maskos U, Elder J K

Abstract excerpt

An efficient method was developed for making complete sets of oligonucleotides of defined length, covalently attached to the surface of a glass plate, by synthesizing them in situ. A device carrying all octapurine sequences was used to explore factors affecting molecular hybridization of the teth...

Topics

Base Sequence
DNA
Molecular Sequence Data
Mutation
Nucleic Acid Hybridization
Nucleic Acids
Oligonucleotides
RNA

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